Shohei Ohtani hit his major league-leading 40th home run in a stellar offensive outing following an early exit from the mound, but his Los Angeles Angels could not hold on to the lead in an agonizing 5-3 loss Thursday to the Seattle Mariners.

The Mariners came back to win the battle of American League West divisional rivals as Cade Marlowe's ninth-inning grand slam erased a 3-1 Angels advantage and consigned Carlos Estevez (5-2) to his first blown save of the season.

Shohei Ohtani of the Los Angeles Angels hits a solo home run in the eighth inning, his 40th homer of the season, during a game against the Seattle Mariners at Angel Stadium in Anaheim, California, on Aug. 3, 2023. (Kyodo)

Ohtani went 2-for-2 with two walks and scored the tying run at 1-1 following his 14th stolen base at Angel Stadium, where cramping on the middle finger of his right hand cut his pitching start to four scoreless innings.

The Angels led 2-1 in the bottom of the eighth before the AL Player of the Month for June and July added an insurance run by launching a long bomb 390 feet out to right field.

"I wanted to have a positive at-bat there, even if it was a walk," Ohtani said. "I wasn't necessarily thinking home run."

"I reacted well to that pitch on the corner, and watched it as it went out. When I get a fat pitch, I want to be prepared to put my best swing on it."

Coming off the first complete-game shutout of his major league career, Ohtani had thrown just 59 pitches by the time he was relieved by right-hander Jose Soriano.

The runaway AL MVP favorite had to work hard in the opening frame as he escaped a first-and-third, no-out jam with help from third baseman Mike Moustakas, who made the final out after fielding Ty France's grounder barehanded.

Ohtani appeared to be sailing more smoothly on the mound when he departed with the game still scoreless. He struck out four while allowing three hits and a walk.

Eugenio Suarez's opposite-field home run put the Mariners on the board in the top of the sixth before the Angels rallied back in the home half of the inning.

Ohtani sparked the rally by stealing second base after Seattle starter Bryan Woo declined to throw him strikes and walked him. Ohtani then scored the tying run on C.J. Cron's grounder before Moustakas made it 2-1 with his RBI double.

The Angels' loss leaves them four games back from the Toronto Blue Jays in the race for the third and final AL Wild Card berth.

Shohei Ohtani of the Los Angeles Angels, wearing a home run celebration prop, high-fives teammates after hitting a solo shot, his 40th homer of the season, during a game against the Seattle Mariners at Angel Stadium in Anaheim, California, on Aug. 3, 2023. (Kyodo)

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