Iran strongly condemned the U.S.-led air strike Saturday on Syria, and warned the United States and its allies Britain and France of unspecified consequences.

"This amounts to a flagrant breach of international laws and principles, a violation of Syria's right to national sovereignty and territorial integrity," the Foreign Ministry said in a statement.

"Incontrovertibly, the U.S. and its allies are responsible and should be held accountable for the consequences of this adventurism both in the region and beyond," it said.

In comments to foreign diplomats in Tehran, Supreme Leader Ayatollah Ali Khamenei, who is the commander of Iran's armed forces, described the leaders of the United States, France and Britain as "criminals" for ordering the joint assault.

(Iranian Supreme Leader Ayatollah Ali Khamenei, Photo courtesy of the Office of Iranian Supreme Leader, UPI/Kyodo)

The "attack on Syria is a crime. I firmly declare that the presidents of the United States and France and the British prime minister committed a major crime. They will gain no benefit," Khamenei's official website quoted him as saying.

Separately, a high-ranking commander of the Iranian Revolutionary Guard Corps, which has been fighting alongside the military of Syrian President Bashar al-Assad from the start of the Syrian war, said the United States and its allies now await the consequences of their strike on Syria.

"The U.S.-led coalition's strike on Syria will make the regional situation more complicated. This complicated situation will be against U.S. interests. Americans will be responsible for further incidents in the region," Tasnim News Agency quoted the deputy IRGC commander for political affairs, Gen. Yadolla Javani, as saying.

U.S. President Donald Trump said Friday (U.S. time) the United States, Britain and France had launched precision strikes targeting sites in Syria associated with the chemical weapons capabilities of the Assad regime.

Trump ordered the strikes to punish the Assad government for an alleged chemical weapons attack on a rebel-occupied area near Damascus last weekend that reportedly killed more than 40 people, including children.

It was the second U.S. military strike against the Assad regime prompted by its alleged use of banned chemical weapons against rebels during a civil war that began in March 2011. The first air strike ordered by Trump occurred in April last year.

Trump condemned Russia and Iran for their ties to the regime, saying they are "most responsible for supporting, equipping and financing the criminal Assad regime."

"To Iran and to Russia, I ask: What kind of a nation wants to be associated with the mass murder of innocent men, women and children?"

The Syrian government has denied using chemical weapons against enemy forces. Iran and Russia also said no chemical weapons were used by Syrian government forces last weekend, calling the claim it had "an excuse for attack."