Shohei Ohtani hit his eighth home run of the season and his first in May in the Los Angeles Angels' 5-4 loss to the Houston Astros on Wednesday.
Ohtani's two-run shot to right in the ninth inning off Astros closer Ryan Pressly brought the game within a run, but the Angels fell short despite putting runners on first and second with no outs at Angel Stadium.
The two-way star went 1-for-4, striking out twice and flying out in his other at-bats.
The Angels have lost both three-game sets against division rivals the Texas Rangers and the Astros two games to one.
Houston starting pitcher Cristian Javier (3-1) allowed two runs and struck out 11 over six innings.
Jeremy Pena singled in two runs to cap the Astros' four-run fourth that put them ahead 5-2. Griffin Canning (2-1) took the loss.
At Wrigley Field, Chicago Cubs outfielder Seiya Suzuki had an RBI double among his two hits in a 10-4 victory over the St. Louis Cardinals, their first win in four games.
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