Shohei Ohtani went 2-for-4 with a run scored Saturday for the Los Angeles Angels, who gave up an early lead in a 4-3 loss to the Detroit Tigers.

Batting leadoff as the designated hitter, Ohtani doubled before coming home on Luis Rengifo's single for a 1-0 lead in the first inning at Comerica Park.

The Halos went up 2-0 on Andrew Velazquez's solo homer in the second, but the Tigers erased the advantage with two runs in the bottom of the inning.

Shohei Ohtani of the Los Angeles Angels hits a double in the first inning of a baseball game against the Detroit Tigers at Comerica Park in Detroit, Michigan, on Aug. 20, 2022. (Kyodo)

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After both teams added a run in the third, Detroit scored the go-ahead run on Victor Reyes' RBI single in the fifth.

Detroit reliever Alex Lange struck out Ohtani and fellow All-Star Mike Trout back-to-back in the seventh to preserve the lead.

At Wrigley Field, Seiya Suzuki went 1-for-5 for the Chicago Cubs, who extended their win streak to five after walking off with a 6-5 victory over the Milwaukee Brewers in 11 innings.